Science Inventory

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Bioinformatics is the combination of information science, mathematics, and biology to answer biological questions, typically pertaining to the exploration of large volumes of DNA and/or amino acid sequence data. The major advantages of such approaches are that complex data can be...

The global regulatory landscape surrounding chemical safety is shifting away from animal testing and moving toward greater reliance on New Approach Methodologies (NAMs) including a rapid growth in molecular data and computational methods to achieve human and environmental protect...

Defining the taxonomic relevance of an adverse outcome pathway (AOP) can aid in extrapolation of knowledge from tested model organism to other non-tested species. Recently an adverse outcome pathway network was developed describing the linkages from activation of the nicotinic ac...

- Background and objectives. COVID-19 patients could experience gastrointestinal disorders and alteration of gut microbiota. Besides, the SARS-CoV-2 receptor angiotensin converting enzyme 2 (ACE2) is highly expressed in enterocytes. Thus, it has been proposed that SARS-CoV-2 ente...

Apis bee health has gained significant attention due to the increases in colony death and failure. Chemical stressors, such as neonicotinoid insecticides, along with non-chemical stressors contribute to impact on colonies. In addition to the concern surrounding Apis bee populatio...

Glucocorticoid-mediated bioactivity has been detected in North American surface waters.&nbsp; However, the bioavailability and in vivo potency of glucocorticoid receptor (GR) agonists in environmental mixtures remains undefined. To better understand the sensitivity of in vivo, he...

&nbsp;Thyroid hormones (TH) are critical for brain development. Serum measures of TH are used for regulatory decision-making purposes because of concern for neurodevelopmental disorders and serum T4 represents a key integrator node in the Adverse Outcome Pathway (AOP) upstream fr...

2022 SOT Symposium Speaker 5: Katherine O&rsquo;Shaughnessy Biomarkers of Neurodevelopmental Effect Are Necessary to Interpret Chemical Action In Vivo &nbsp;One of the primary concerns of thyroid disrupting chemicals is their potential impact on neurodevelopment, as thyroid hormo...

Developmental thyroid hormone (TH) insufficiency is associated with various neurodevelopmental disorders in children. Previously, we demonstrated that developmental hypothyroidism alters cell adhesion, migration, and apoptosis in the neonatal rat brain. These abnormalities were l...

Applications that use toxicity test results from ECOTOX (e.g., ecological risk assessment, SSDs, site-specific hazard evaluations) typically incorporate additional toxicity, chemical, and biological data from other sources. The addition of standardized identifiers to ECOTOX incre...

For over a decade, New Approach Methodologies (NAMs) such as structure-activity/read-across, -omics technologies, and Adverse Outcome Pathway (AOP), have been considered within regulatory communities as alternative sources of chemical and biological information potentially releva...

AOP392 &ndash;Fibrinolysis, decreased/Bradykinin, activated leading to increased hyperinflammation, describes Key Events (KE) associated with immune response, leading to the uncontrolled inflammatory response referred to as hyperinflammation. The aim of this work is to understand...

On April 28-29, 2021, 50 scientists from different fields of expertise met for the 3rd&nbsp;online CIAO workshop. The CIAO project &ldquo;Modelling the Pathogenesis of COVID-19 using the Adverse Outcome Pathway (AOP) framework&rdquo; aims at building a holistic assembly of the av...

Contribution, collaboration, and curation of the Adverse Outcome Pathway knowledgebase has enabled data-mining andcomputational knowledge discovery research that utilizes the information within the AOP knowledgebase. One active area of research is the discovery and identification...

The potential for U.S. EPA&rsquo;s SeqAPASS (Sequence Alignment to Predict Across-Species Susceptibility) tool to predict susceptibility of type 3 iodothyronine deiodinase (DIO3) enzyme to chemical inhibition was investigated. The SeqAPASS tool identifies whether known critical a...

Despite decades of investigation, test methods to identify respiratory sensitizers remain an unmet regulatory need. In order to support the evaluation of New Approach Methodologies in development, we sought to establish a reference set of low molecular weight respiratory sensitiz...

The adverse outcome pathway (AOP) is a simplified, organizational construct that links molecular initiating events (MIEs) and early key events (KEs) at lower levels of biological organization to adverse outcomes to support the incorporation of mechanistic data in regulatory appli...

(note: this is the abstract of the review article on which the presentation was based) ABSTRACT: The remarkable advances coming about through nanotechnology promise to revolutionize many aspects of modern life; however, these advances come with a responsibility for due diligence ...

The biomedical literature contains an abundance of information about the activity of chemicals in biological systems, including environmental toxicants of interest to the EPA. The goal of literature informatics research at the EPA&rsquo;s Center for Computational Toxicology and E...

While gene editing technologies such as RNAi, transcription activator-like effector nucleases, and zinc finger nucleases have been in use for years, none offer the ease of use and specificity of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9 approaches to...

<h3>Background</h3> <p>EPA’s Integrated Risk Information System (IRIS) Program is developing an updated assessment of inorganic arsenic. See the chemical information page tab for the most up-to-date information about the status of this assessment.</p> <h4>Assessment History</...

The focus of this meeting is the SAP's review and comment on the Agency's proposed high-throughput computational model of androgen receptor pathway activity as an alternative to the current Tier 1 androgen receptor assay (OCSPP 890.1150: Androgen Receptor Binding Rat Prostate Cyt...

All-trans retinoic acid (ATRA) gradients determine skeletal patterning morphogenesis and can be disrupted by diverse genetic or environmental factors, leading to fetal skeleton malformations. Here, a data-driven model was constructed to identify chemicals associated with both ATR...

Predictive, mechanism-based approaches to assessing the toxicity of contaminant mixtures have been largely limited to chemicals that exert effects through the same biological target/molecular initiating event (MIE). However, through understanding specific pathways through which c...

There is no abstract asociated with this presentation. However, this work provides a high level overview of: &middot;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; The Value of Harnessing Artificial Intelligence (machine learning, natural language processing, and automated data extraction)...